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Abbreviations EC Electronic cigarette HUMITIPAA Human vaping mimetic real-time particle analyzer COPDGene Chronic Obstructive Lung Disease Gene Study FEV1 Forced expiratory volume in the first second FVC Forced vital capacity VEA Vitamin E acetate PG Propylene glycol VG Vegetable glycerin ISO International Organization for Standardization GC–MS Gas chromatography–mass spectroscopy LAA % Of low attenuation areas in density mask analyses of chest CT scans MMRC Modified Medical Research Council GOLD Global initiative for obstructive lung disease PRISM Preserved ratio impaired spirometry Author contributions KHB conceived the study design

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